14 獅子島産群体ボヤに含まれる新規抗魚病細菌性セリノリピッドの単離と構造決定(口頭発表の部)

概要

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Fish and shellfish diseases are the most serious concerns for aquaculture today. Large amounts of antibiotics are used to control these diseases which may pose environmental and hygienic problems. In our search for environmentally-friendly drugs for aquaculture from Japanese invertebrates, we found that the extract of an unidentified marine tunicate collected in southern Japan exhibited activity against the bacterium Vibrio anguillarum, a causative agent of the Vibriosis in fish. Bioassay-guided fractionation afforded two novel serinolipid derivatives named shishididemniols A (1) and B (2). The structure of shishididemniol A (1) was elucidated by interpretation of spectral data, and the application of the modified Mosher method to 1 and its suitable degradation products. Shishididemniol B (2) was the chlorohydrin of 1, which was demonstrated by chemical interconversion. Compounds 1 and 2 exhibited antibacterial activity against fish pathogenic bacterium Vibrio anguillarum.
2006-09-15