7 海綿Mycale sp.から得られた抗カビ牲マクロライドの構造(ポスター発表の部)

概要

論文の詳細を見る
In the course of our search for bioactive metabolites in Japanese marine invertebrates, we encountered a sponge of the genus Mycale collected in Gokasho Bay, Mie, which showed a marked antifungal activity. From the sponge three antifungal substances, named mycalamides A, B and C, have been obtained by the bioassayguided isolation work. Mycalamides are not only antifungal but also cytotoxic against B-16 melanoma with IC_<50> 0.5-1.0ng/mL. The structure elucidation was done by spectral analyses including extensive 500MHz NMR studies as well as by comparison of the spectral data with those of kabiramides, ulapualides and halichondramide. It was disclosed that mycalamides are novel macrolides embracing a trisoxazole unit and a sidechain with an N-methyl formamide terminus, which are closely related to kabiramides and ulapualides. The present study may, provide an evidence tnat the nudibranch macrolides originate from marine sponges which nudibranchs prey on.
天然有機化合物討論会の論文
1988-09-26