50 ウミウシ卵の抗カビ性マクロライドkabiramide類の構造

概要

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Five antifungal macrolides, kabiramide A-E, have been isolated from the unidentified nudibranch eggmasses collected at the Kabira Bay, Okinawa Prefecture. These compounds are not only antifungal but also inhibitory against cell division of fertilized starfish eggs at low concentrations; 1ug/ml for kabiramide A and 0.2ug/ml for other kabiramides. The structure of kabiramide C, the major component, was elucidated by extensive NMR experiments including 2D-NMR (homo- and hetero-nuclear COSY) and LSPD studies. Kabiramide C is a macrolide containing an unprecedented trioxazole moiety and a side chain with an N-methyl formamide terminus. Kabiramides A, B, D, and E are supposed to possess essentially the same structures as that of kabiramide C except for some functional groups.
天然有機化合物討論会の論文
1985-09-07