29 ポリセオナミド類の構造(口頭発表の部)

概要

論文の詳細を見る
Polytheonamides are potent cytotoxic metabolites isolated from the marine sponge Theonella swinhoei. The ^1H and ^<13>C NMR spectra indicated polytheonamide B to be a polypeptide with unusual residues. Due to the blocking of the N-terminal amino group and the presence of many unusual residues, the methodology of structure elucidation for proteins was not applicable. The acid hydrolysate of polytheonamide B was analyzed by amino acid analysis and 2D NMR which disclosed most of the component amino acid residues. With this knowledge, interpretation of 2D NMR data was effected leading to the sequence of the 48 reside peptide. The structure of the 44th residue was elucidated on the basis of the elemental analysis and spectral data. Polytheonamide A gave the same oxidation product as polytheonamide B indicating that they are isomeric at the sulfoxide in the 44th residue.
天然有機化合物討論会の論文
2001-09-01