8 海産二枚貝から抗酸化物質として単離した新規Chlorophyll a 関連化合物(口頭発表の部)

概要

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We focused our research interests into surveying new antioxidants among the extracts of marine organisms. Among the organic solvent extracts of viscera of marine fish and bivalves, the extract of the short-necked clam, Ruditapes philippinarum, showed very low POV in the conventional antioxidant test. From the extract, new chlorophyll a related compounds, chlorophyllone a (1), C_<33>H_<32>N_4O_3, and chlorophyllonelactone a (2), C_<33>H_<32>N_4O_4 and an unknown compound (3) as well as pyropheophorbide a (4) were isolated as main antioxidative compounds. We were interested in the origin of these compounds and surveyed them in the extracts of the other bivalves, the scallop Patinopecten yessoensis and the oyster Crassostrea sp., to isolate 2, 3, 4 and 10-epichlorophyllone a (5) and 1, respectively. Spectroscopic analysis allowed us to assign the interesting structures with additional ring VI to these new chlorophyll a related compounds. This suggests the presence of another new degradation pathway of chlorophyll a. From the extract of attached diatoms mixture mainly containing Fragilaria oceanica, Nitzschia closterium, etc. cultured for culturing juvenile abalone, 1 was isolated, suggesting that these new chlorophyll a related compounds are not artifact formed in the bivalves' viscera, but produced by microalgae. The origin is now under investigation.
天然有機化合物討論会の論文
1990-09-25