Mode of Action of Polygodial, an Antifungal Sesquiterpene Dialdehyde(Biological Chemistry)
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概要
- 論文の詳細を見る
The mechanism of polygodial antifungal action was studied using Saccharomyces cerevisiae. It inhibited the incorporation of radioactive precursors into macromolecules in whole cells. However, no specificity in the inhibition of precursor incorporation was observed among various species of macromolecules, i.e., DNA, RNA, protein, and polysaccharide. It also inhibited the exogenous but not endogenous respiration of the cells. Polygodial greatly enhanced the leakage of cellular constituents from the treated cells, and the examination under an electron microscope revealed structural damage of the cell membranes of treated cells. These results support the conclusion that polygodial acts primarily by damaging the permeability barrier of the yeast cells.
- 社団法人日本農芸化学会の論文
- 1988-06-23
著者
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Taniguchi M
Graduate School Of Science Osaka City University
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Hashimoto K
Keio Univ. Yokohama Jpn
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Yano Y
Faculty Of Science Osaka City University
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HARAGUCHI Hiroyuki
Faculty of Engineering, Fukuyama University
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TANIGUCHI Makoto
Faculty of Science, Osaka City University
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Oi Susumu
Department of Biology, Faculty of Science, Osaka City University
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Hashimoto Kimiko
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Taniguchi Makoto
Graduate School Of Science Osaka City University
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Kubo I
Division Of Entomology And Parasitology College Of Natural Resources University Of California
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Kubo Isao
Division Of Entomology And Parasitology College Of Natural Resource University Of California
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Taniguchi M
Osaka City Univ. Osaka Jpn
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HASHIMOTO Kensuke
Faculty of Engineering, Fukuyama University
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OI Susumu
Faculty of Science, Osaka City University
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YANO Yoshihisa
Faculty of Science, Osaka City University
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TADA Etsuo
Faculty of Science, Osaka City University
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IKENISHI Kohji
Faculty of Science, Osaka City University
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Tada E
Faculty Of Science Osaka City University
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Ikenishi Kohji
Faculty Of Science Osaka City University
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Oi Susumu
Faculty Of Science Osaka City University
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Oi S
Osaka City Univ. Osaka Jpn
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Taniguchi M
Department Of Bio- And Geoscience Graduate School Of Science Osaka City University
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Taniguchi M
Taiyo Kagaku Co. Ltd. Mie Jpn
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Hashimoto Kensuke
Faculty Of Engineering Fukuyama University
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Haraguchi Hiroyuki
Faculty Of Science Osaka City University
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Haraguchi Hiroyuki
Faculty Of Engineering Fukuyama University
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Haraguchi Hiroyuki
Fac. Engineer
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Taniguchi Makoto
Faculty Of Science Osaka City University
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