Structure-Activity Relationship of the Warburgia Sesquiterpene Dialdehydes
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概要
- 論文の詳細を見る
Sesquiterpene dialdehydes, isolated originally as insect antifeedants from East African Warburgia trees, have been shown to exhibit strong antimicrobial activity. Their chemical reactivities and biological activities were investigated in comparison with those of related compounds. There was a good correlation between the antifungal activity and the papain inhibitory activity of these compounds. Both activities appear to result from their highly specific reactivity with sulfhydryl groups. Consideration of the structure-activity relationships led to the proposal of a structure unit, the enal-aldehyde moiety, that is essential to biological activity.
- 社団法人 日本農芸化学会の論文
著者
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Adachi Takeshi
Department of Biochemistry and Integrative Medical Biology, Keio University of Medicine
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Kubo Isao
Division Of Entomology And Parasitology College Of Natural Resource University Of California
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Kimura Akihiko
Institute Of Advanced Energy Kyoto University
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Oi Susumu
Department Of Biology Faculty Of Science Osaka City University
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Katsumura Shigeo
Institute Of Organic Chemistry Faculty Of Science Osaka City University
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Isoe Sachihiko
Institute Of Organic Chemistry Faculty Of Science Osaka City University
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Taniguchi Makoto
Department Of Bio- And Geoscience Gradaute School Of Science Osaka City University
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Taniguchi Makoto
Department of Biology, Faculty of Science, Osaka City University
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