Potent Suppressive Activity of Pheophytin a and b from Non-Polyphenolic Fraction of Green Tea(Camellia sinensis)against the Activation of Oxygen Radical Generation, Cytokine Release and Chemotaxis of Human Polymorphonuclear Neutrophils(PMNs)

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概要

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• Recently, chlorophyll-related compounds, pheophytin a and b have been identified as antigenotoxic substances in the non-polyphenolic fraction of green tea leaves, which suppressed umu C gene expression in tester bacteria induced by various genotoxic substances(Okai and Higashi-Okai, Cancer Lett., 107 : 117-123, 1997). To study the anti-inflammatory activity of these pigments, the authors analyzed the inhibitory effects of pheophytin a and b from green tea against functional activation of human polymorphonuclear neutrophils(PMNs)using in vitro cell culture experiments. (i)Pheophytin a and b from green tea caused a significant suppression against the opsonized zymosan-induced chemiluminescence in human PMNs in a dose-dependent fashion. (ii)Pheophytin a and b also exhibited suppressive effects on the release of an inflammatory cytokine, interleukin-1 β from human PMNs stimulated by E. coli lipopolysaccharide. (iii)Pheophytin a and b showed a significant suppression against Formyl-Met-Leu-Phe(FMLP)-induced chemotaxis of human PMNs in a dose-dependent manner in Boyden's chamber experiment. These results suggest that pheophytin a and b from non-polyphenolic fraction of green tea have potent suppressive activities against the activation of human PMNs associated with inflammatory reactions.

• 公益社団法人日本生物工学会の論文
• 1998-06-25

著者

• Okai Yasuji

  Department Of Human Life Science Osaka Kun-ei Women's College Showjaku

• Taniguchi Makoto

  Department Of Biology Faculty Of Science Osaka City University

• HIGASHI-OKAI KIYOKA

  Department of Human Life Science, Osaka Kun-Ei Women's College, Showjaku

• Higashi‐okai K

  Osaka Kun‐ei Women's Coll. Osaka Jpn

• Taniguchi Makoto

  Department Of Bio- And Geoscience Gradaute School Of Science Osaka City University

• Higashi-Okai Kiyoka

  Department of Human Life Science, Osaka Kun-Ei Women's College, Showjaku

• TANIGUCHI Makoto

  Department Medical Research Institute Kanazawa Medical University

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