Scintigraphic Detection of Regional Disruption of the Adrenergic Nervous System in Sarcoid Heart disease

概要

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The presence of defects on resting thallium (^<201>Tl) myocardial scintigraphy has been previously demonstrated in myocardial sarcoidosis. To examine cardiac sympathetic nerve activity in patients with cardiac sarcoidosis, we performed ^<201>Tl and I-123 MIBG (meta-iodobenzylguanidin) myocardial scintigraphy in patients with sarcoidosis. Sixteen patients with sarcoidosis were classified into 2 groups according to the presence or absence of defects on ^<201>Tl scintigraphy. Myocardial images by both ^<201>Tl and I-123 MIBG were then divided into 20 segments and scored using a 6-point scoring system. Defect Score was defined as a the sum of significant scores in each image. The mean Defect Score in I-123 MIBG images was higher in the ^<201>Tl defect group (44.3±13.3) than in both the normal ^<201>Tl group (25.1±10.5) and the control group (22.7±11.4). Moreover, the locations of defects on I-123 MIBG scans were consistent with those on ^<201>Tl scans. This study suggests that cardiac adrenergic function may be impaired in cardiac sarcoindosis, and I-123 MIBG scintigraphy may be more sensitive in detecting cardiac sarcoidosis than ^<201>Tl scintigraphy, although the clinical significance of these findings requires further study.
社団法人日本循環器学会の論文
1996-09-20