Effects of Phospholipids on the Oligomeric State of Phospholamban of the Cardiac Sarcoplasmic Reticulum
スポンサーリンク
概要
- 論文の詳細を見る
Background Phospholamban is a reversible inhibitor of the Ca^<2+>-ATPase of the cardiac sarcoplasmic reticulum (SR) and contributes to the regulation of heart muscle contractility. Because only the monomeric form, not the pentameric form, of phospholamban inhibits the Ca^<2+>-pumping activity of the SR, it is important to understand the dynamic equilibrium between these 2 forms. Methods and Results The effects of various detergents and phospholipids on the oligomeric state of phospholamban were examined. Among the detergents examined, 3-[(3-cholamidopropyl) dimethylammonio]-l-propanesulfonate (CHAPS) stabilized the pentameric form whereas octylglucoside was an effective inducer of dissociation into the monomer. On the basis of these properties of the 2 detergents, the effects of various phospholipids on the oligomeric state of phospholamban with the use of mixed micelles containing octylglucoside or CHAPS were examined. Among the 8 phospholipids examined, phosphatidic acid was an effective inducer of pentamer dissociation, whereas the other phospholipids exhibited pentamer-stabilizing activity. Lysophosphatidylcholine, lysophosphatidylethanolamine, and phosphatidylglycerol were highly effective stabilizers of the pentamer. Conclusions The phospholipids in the SR membrane are important determinants of the equilibrium between the monomeric and pentameric forms of this protein. The results suggest that the metabolism of phospholipids in the cardiac SR may contribute to regulation of heart muscle contractility by shifting this equilibrium.
- 2005-08-20
著者
-
Kimura Yoshihiro
Department Of Cardiology Higashi-osaka City General Hospital
-
Inui Makoto
Department Of Pharmacology Yamaguchi University School Of Medicine
-
Zhang Xiao
Department Of Biology Faculty Of Science Kyushu University
-
Zhang Xiao
Department Of Pharmacology Yamaguchi University School Of Medicine
-
Kimura Yoshihiro
Department Of Applied Physics Defence Academy
-
Kimura Yoshihiro
Department Of Pharmacology Yamaguchi University School Of Medicine
関連論文
- Effect of Early Use of Low-Dose Pravastatin on Major Adverse Cardiac Events in Patients With Acute Myocardial Infarction : The OACIS-LIPID Study
- Impact of Smoking Status on Long-Term Mortality in Patients With Acute Myocardial Infarction
- Impact of 87 Gene Polymorphisms on Mortality and Recurrent Events After Myocardial Infarction(Acute Myocardial Infarction, Clinical (Pathophysiology) 6 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Myocardial Rest Iodine-123-β-Methyl-Iodophenyl-Pentadecanoic Acid Scintigraphy Compared with Dipyridamole Stress Thallium-201 Scintigraphy in Unstable Angina
- Effects of Phospholipids on the Oligomeric State of Phospholamban of the Cardiac Sarcoplasmic Reticulum
- THE ROLE OF CORONARY ARTERY SPASM AND CORONARY ARTERY SCLEROSIS IN UNSTABLE ANGINA : Ischemic Heart Disease (V) : V : 48 Annual Scientific Meeting, Japanese Circulation Society
- NEW TYPES OF ARRHYTHMIA REVERSION SYSTEMS AGAINST TACHYARRHYTHMIA : Arrhythmias (III) : V : 48 Annual Scientific Meeting, Japanese Circulation Society
- E314 Application of a Soft Computing Method in Judgement on Characteristic of Coal Ash Slagging
- Scintigraphic Detection of Regional Disruption of the Adrenergic Nervous System in Sarcoid Heart disease
- LONG TERM EFFICACY OF EMERGENCY PTCA IN AMI : PROTECTIVE EFFECT TO RECURRENT ISCHEMIC EVENTS IN AMI : PTCA, Thrombosis : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- EFFECT OF OPC-8212 ON LEFT VENTRICULAR FUNCTION IN PATIENTS WITH CHRONIC LEFT VENTRICULAR FAILURE : AN ASSESSMENT WITH RADIONUCLIDE ANGIOGRAPHY : Heart Failure, Cardiotonic Drugs : FREE COMMUNICATIONS (V) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETIN
- CAPACITY OF CORONARY CIRCULATION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY : Hemodynamics, Cardiac Function (IV) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- Effect of Smoking Cessation on Long-Term Mortality in Patients with Acute Myocardial Infarction
- Apoptosis Occurs in Granulosa Cells but not Cumulus Cells in the Atretic Graafian Follicles in Multiparous Pig Ovaries
- 1.Quantity of mandible bone in osteoporosis model rats(12th Annual Meeting of the Society of Hard Tissue Biology)
- LEFT VENTRICULAR FILLING DYNAMICS AND CARDIAC PACING : A STUDY BY PULSED DOPPLER ECHOCARDIOGRAPHY : Echocardiography (I) : FREE COMMUNICATIONS (III) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE EFFECT OF REDUCTION OF CORONARY STENOSIS BY PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY ON THROMBOXANE PRODUCTION IN THE CORONARY CIRCULATION : Ischemic Heart Disease (II) : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETI
- FOLLOW UP DATA OF CORONARY ANGIOGRAM IN THE CASES OF SUCCESSFUL PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY : Ischemic Heart Disease (IV) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- Diagnosis of small hepatic nodules detected by surveillance ultrasound in patients with cirrhosis : Comparison between contrast-enhanced ultrasound and contrast-enhanced helical computed tomography
- EFFECT OF PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY ON SYNTHESIS OF THROMBOXANE A_2 AND FIBRIN FORMATION : PTCA, Thrombosis : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -10-EFFECTS OF ACUTE PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY FOR ACUTE MYOCARDIAL INFARCTION : RELATION OF RESIDUAL STENOSIS WITH WALL MOTION
- Specialized host-plant performance of the cotton aphid is altered by experience
- EFFECT OF OPC-8212 (2(1H)-QUINOLINONE), A NEW INOTROPIC AGENT, ON MYOCARDIAL ENERGY METABOLISM IN PATIENTS WITH CORONARY HEART DISEASE
- Ca2+/Mg2+-Dependent Endonuclease but not Ca2+-Dependent, Mg2+-Dependent or Cation-Independent Endonuclease is Involved in Granulosa Cell Apoptosis of Pig Atretic Follicles
- Ca^/Mg^-Dependent Endonuclease but not Ca^-Dependent, Mg^-Dependent or Cation-Independent Endonuclease is Involved in Granulosa Cell Apoptosis of Pig Atretic Follicles
- Osteoinductive Activity of Bio-Ceramics with BMP Composites : Quantitative Analysis of New Bone Formation Induced by HAP-BMP composites
- Osteoinductive Activity of Bio-Ceramics with BMP Composites : Quantitative Analysis of New Bone Formation Induced by HAP - BMP composites
- DC Electroluminescence in Thin Films of Zinc Sulfide
- 3Z-8 Detecting Sub-Marine Attack with Safe-triangle and GPS in Ad hoc Network
- ANALYSIS OF PLASTIC STENTS IN THE TREATMENT OF LARGE COMMON BILE DUCT STONES IN 45 PATIENTS
- N-Bromosuccinimide-Fluorescein Based Sensitive Flow-Injection Chemiluminescence Determination of Phenformin
- Nitric Oxide Inhibits Blue Light-Specific Stomatal Opening Via Abscisic Acid Signaling Pathways in Vicia Guard Cells
- Adipose tissue-targeted 11β-hydroxysteroid dehydrogenase, type 1 inhibitor protects against diet-induced obesity
- The Chlorination of Cyclooctadiene with Cupric Chloride in Acetonitrile Containing Lithium Chloride
- Selective blockade of dopamine D-1 receptor by SCH 23390 affects dopamine agonist binding to 3H-spiperone labeled D-2 receptors in rat striatum.