アズレン口腔内塗布剤の調製と安定性

概要

論文の詳細を見る
For the topical application to the treatment for stomatitis, six oral cavity viscous fluids containing 0.1% sodium guaiazulene sulfonate (SGAS) were prepared with 4% methylcellulose, 2% sodium acrylate or 4% hydroxypropylcellulose (HPC) as viscous liquids, procaine or lidocaine as analgesics. Examination of the stabilities of SGAS in each preparation based on its absorbency showed that SGAS was most stable in the preparation containing HPC and procaine, stored in light-resistant containers below 4℃ for 5 weeks. Retaining of SGAS after gingivo-buccal application was examined. Concentration of SGAS in saliva was declined according to the first-order rate process. HPC was observed to provide adequate retainability to the preparation. Elimination constant was 4.8×l0^-2/min, and half-life was 14.2 minutes. With these results it is concluded that the SGAS oral cavity viscous fluid consisting of HPC and procaine is most efficacious to the treatment for stomatitis and lichen planus among six preparations. The present preparation was very efficacious clinically. Some patient, having depended on intubation feeding, recuperated enough to eat food orally.
日本医療薬学会の論文
1990-04-20