Intraarterial injection chemotherapy using water-in-oil(W/O) state cisplatin-lipiodol emulsion(CPLEM) for hepatocellular carcinoma.

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For the treatment of hepatocellular carcinoma by intra-hepatic arterial injection, CDDP-Lipiodol emulsion (CPLEM) was prepared.<BR>CPLEM was in a water-in-oil state, and showed moderate retaining and releasing of CDDP.<BR>Clinically, 9 patients with advanced hepatocellular carcinoma underwent the transarterial chemo-embolization by CPLEM. Partial response was observed in 2 cases, and minor response 1 case. AFP decreased considerably, and side effects were slight.<BR>Serum platinum concentrations after administration were low. Deconvolution of the present data was demonstrated, and leakage of CDDP from liver was supposed to be gradual.<BR>In conclusion, CPLEM was considered to be useful for mild chemo-embolization in a treatment of hepatocellular carcinoma.