人参養栄湯に関する薬理学的基礎研究 : 第二報人参養栄湯長期投与による生体内フリーラジカルおよび過酸化脂質の動態

概要

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Ninjin-yoei-to was administered to mice orally for 5 weeks, and the effects on free radical and lipid peroxidation were investigated. In this study, we investigated the changes with leukocytes priming and lipid peroxidation by measuring the luminol-enhanced CL. Administration of Ninjin-yoeito showed suppressive action on CL from leukocytes stimulated PMA. While, it was increased significantly a lipid peroxidation of plasma, brain and liver compared with that of control. The effects of Ninjin-yoei-to at concentration of 1 to 0.001 mg/ml on CL from leukocytes stimulated PMA and lipid peroxidation of mouse plasma, brain and liver homogenate were investigated, in vitro. The CL from leukocytes stimulated PMA and lipid peroxidation of mouse plasma, brain homogenate were inhibited by the addition of Ninjin-yoei-to, the suppressive effect was also dependent on the concentration. These results suggest that the suppressive effect on the CL from leukocytes stimulated PMA by Ninjin-yoei-to is at least in part due to its radical trapping action and inhibition of superoxide production.
和漢医薬学会の論文
1999-08-25