塩酸ツロブテロール製剤の薬剤学的研究

概要

論文の詳細を見る
In order to obtain information on the compatibility of Berachin Dry Syrup (BE.D.S.) with drugs in common use, two presentation of the mixtures were investigated : powder (27 drugs) and solution (20 drugs) preparation. Forty seven drugs were studied by sensory test, and solution preparation (20 drugs) was investigated for changes in redispersibility, viscosity, pH and buffer capacity curve. BE. D. S. residual amouut (%) was measured by absorptiometry and high-performance liquid chromatography. The changes with time were analyzed by scoring and subject to a time series analysis (by 2 mean vector). A significant change was observed for 6 of the 27 drugs in the wetting under the severe condition (30℃, R. H. 92%), and no change for solution was observed. In solution, a significant change wasn't observed in redispersibility, viscosity, pH, and buffer capacity curve. BE.D.S. was almost stable in 2 weeks under any condition tested. The above results show that BE.D.S. can be kept in the mixtures with various syrups under the best and moderate condition.
日本医療薬学会の論文
1987-02-20