多剤同時投与並びに薬剤間の物理化学的相互作用 : その1 : タリビッド錠中オフロキサシンの溶出について

概要

論文の詳細を見る
The multi-drug administration in our hospital was studied on the basis of the survaillance of prescriptions. The elderly patients tended to be prescribed the multi-drugs in a single dose. One of the prescriptions which included 12 pharmaceuticals in a single dose was selected, in which Tarivid, Polaramine, Ursosan, Pydoxal, Loxonin, Gaster, Adalat-L, Alfarol, Salazopyrin, Nadic, PL granules and Mucosolvan were described Dissolution tests of ofloxacin from Tarivid at pH 1.2 or pH 6.8 were performed with or without the co-existence of other drugs. The dissolution of ofloxacin from the tablet was inhibited up to 77.7% at pH 6.8 in the co-existence of other 11 drugs, In the case of this patient, whose pH of inside stomach tends to be neutral with aging, the dissolution of ofloxacin from the tablet may not so be performed as to be found in young patients. There were no indication of interference with other drugs described in the Products information to inhibit the dissolution of ofloxacin from the tablet, but it was suggested that the excipients which were composed of magnesium stearate in Loxonin and Nadic, calcium citrate in Pydoxal and carboxymethylcellulose calcium in Nadic could interfere with the dissolution of ofloxacin.
日本医療薬学会の論文
1992-03-20