口腔用2%セファランチン軟膏の調製とその臨床応用

概要

論文の詳細を見る
For the topical application to the treatment of leukoplakia and lichen planus, four oleaginous oral ointments containing 2% of cepharanthin were prepared with oleaginous bases; white petrolatum with liquid paraffin, white petrolatum: plastibase (3:2) with liquid paraffin, white petrolatum: plastibase (1:1) with liquid paraffin, and plastibase. Consistency of four ointments measured with penetrometer, and spreadability measured with spreadmeter was not changed when these ointments were kept at 20°or 30℃ for 21 days. The stabilities of cepharanthin in each ointment measured with pH meter and spectrophotometer showed that cepharanthin was very stable in each ointment for 21 days at 20°or 30℃. Adhesion time of each ointment was measured using 1% methylrosaniline chloride as an indicator dye. Among four oleaginous bases, plastibase seemed to be the most useful base for clinical application judging from several sensory tests and clinical tests. With these results it is concluded that cepharanthin oral ointment consisting of plastibase is the most effective to the treatment of leukoplakia and lichen planus among four oleaginous ointments prepared.
日本医療薬学会の論文
1989-02-20