Determination of D-Amino Acids in Serum from Patients with Renal Dysfunction

概要

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D-Ala and D-Ser were detected in the sera of both normal subjects and patients with renal dysfunction, and their concentrations were higher in the patients than in the normal subjects. A positive correlation between the concentration of D-Ala or D-Ser and that of creatinine (r=0.733,p<0.001 or r=0.634,p<0.001) or blood urea nitrogen (BUN) (r=0.449,p<0.05 or r=0.629,p<0.001) was observed in sera from 20 patients with renal dysfunction. The fraction (%D) of D-Ala in the total Ala in serum ([D/(D+L)]×100) correlated well with the concentration of creatinine (r=0.811,p<0.001), suggesting that it is a candidate as a marker for renal proximal tubular dysfunction. The correlations of %D of Ser with creatinine and BUN levels were 0.796 (p<0.001) and 0.919 (p<0.001), respectively, indicating that %D of Ser may reflect protein turnover or catabolism in certain tissues as well as renal proximal tubular dysfunction.
社団法人日本薬学会の論文
1995-08-15