口腔用 2% エテンザミド軟膏の調製と臨床適用

概要

論文の詳細を見る
We have already demonstrated that 2% aspirin oral ointment is useful for painful diseases of the oral mucosa. however, the aspirin in the ointment degradates gradually at room temperature. In this study, we investigated the efficiency of the stable salicylic acid derivative ethenzamide, as an agent for such oral ointment. The consistency, spreadability and stability of 20% ethenzamide oral ointment, which was kept at 5℃, 20℃ and 30℃, were detemined by penetrometer, spreadmeter and HPLC, respectively. we also investigated its antinociceptive effect based on the Randall-Selitto paw pressure test in rats, and then compared the findings with the effect of aspirin ointment. In addition eight patients suffering from oral mucous diseases were treated with this 2% ethenzamide oral ointment. and then the clinical effects of the two ointments were compared. These experiments indicated that 2% ethenzamide oral ointment was more stable than aspirin oral ointment, however, no significant difference was observed between them except for stability. Therefore, on account of its stability, 2% ethenzamide oral ointment is thes considered to be more effective than aspirin ointment in the treatment oral mucosal diseases.
日本医療薬学会の論文
1996-12-10