院内製剤アズノール・エレース・キシロカイン含嗽液 (AEXG) の安定性と臨床適用

概要

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A solution comprising sodium azulene sulfonate, lidocaine hydrochloride and Elase (fibrinolysin and DNase) is used as a gargle to relieve the pain after the operation of malignant tumor of the head and neck and to remove exudata from the inflammed part. Azulene sufonate and lidocaine in Azunol・Elase・Xylocaine gargle (AEXG) were stable when kept at 5゜±1, 20°1 and 30°±1 over a 14-day period. However, the activities of fibrinolysin and DNase in AEXG rapidly decreased even at 5°. These results demonstrated that AEXG is unstable and should be prepared just prior to use. However, AEXG produced a remarkable pain relieving effect with few adverse reactions. And AEXG is clinically evaluated highly in spite of its unstability.
日本医療薬学会の論文
1995-08-10