アスピリン親水性軟膏の調製およびその慢性関節リウマチ病への適用

概要

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For the topical treatment of rheumatalgia arthritis, four kinds of 2% aspirin washable ointments using crotamiton (formula 1), crotamiton with 2% anhydrous sodium sulfate (formula 3), crotamiton with 5% anhydrous sodium sulfate (formula 4) and isopropanol (formula 2) as solubilizers, respectively, were prepared. Stability of aspirin in aspirin ointments (4 kinds) was examined by HPLC with UV detection. Aspirin in any ointments was stable for 21 days at 5℃, but unstable at 20℃ and 30℃. Among 4 formulas, formula 1 gave the best results on the sensory tests. Five patients with rheumatalgia arthritis were treated with the 2% aspirin ointment (formula 1). The pain of the patients was relieved moderately or markedly. The pain started to fade within 5-15 minutes and the pain relief usually lasted for 1-8 hours after treatment. With respect to the pain relief, the ointment (formula 1) was the most effective as compared with the indometacin ointment and cataplasm (cold type). From these results, 2% aspirin ointment (formula 1) appeared to be an effective analgesic for the pain associated with rheumatalgia arthritis.
日本医療薬学会の論文