ヒトにおける簡易経皮吸収測定法の考案 : 2%アスピリン軟膏への適用

概要

論文の詳細を見る
A simple method was newly designed and compared with a conventional method for the measurement of percutaneous absorption of drugs into human skin from ointments. The ointment was put on the gauze (8×17mm) of a sticky plaster, the rear side of which was covered with a selophan tape, and applied to the human skins. At intervals, the residual drug in the ointment was extracted and measured. The percutaneous absorption of the drug was calculated on the residual drug concentration. The absorption of aspirin from 2% aspirin ointment, which was effective for the cure of postherpetic neuralgia, was investigated by the proposed methods using isopropanol extraction and HPLC determination of the residual aspirin in the ointment. There was no great difference between the absorption of aspirin into the arm and that into the backskin of a normal subject. About 35% of the aspirin was absorbed for 7 hours. A similar absorption pattern was observed in the two patients of postherpetic neuralgia. Thus, the proposed method might be useful for measuring absorption of many other drugs and investigating the effect of bases and accelerators on the absorption into the human skins.
日本医療薬学会の論文
1991-08-20