フェロミア^<[○!R]>顆粒の配合変化試験

概要

論文の詳細を見る
Ferromia^<[○!R]> Granules is a newly developed medicine for iron deficiency anemia that contains sodium ferrous citrate as an active ingredient. 23 kinds of drugs (e.g., vitamins, anti-ulcer drugs, digestants, antacids, purgatives and antidiarrheals) which may be admixed with Ferromia^<[○!R]> Granules were tested for compatibilities, determining the changes in appearance and the moisture absorption. The drug samples were wrapped in polyethylene-laminated glassine paper and preserved at 25℃ with 75% RH for 30 days. No change in the appearance of Ferromia^<[○!R]> was observed in its admixtures with 21 drugs, but when admixed with HICEE Granules or sodium bicarbonate, Ferromia^<[○!R]> Granules became brown. This change was considered to result from incompatibility. On investigation it was found that the change in color was due to a reaction of L-ascorbic acid in HICEE Granules with sodium ferrous citrate in Ferromia^<[○!R]> Granules. Ferromia^<[○!R]> Granules was not hygroscopic by itself and it was shown that the extent of moisture absorption by admixtures of Ferromia^<[○!R]> Granules with other drugs was almost the same as that of each particular drug.
日本医療薬学会の論文
1988-06-20