乳糖分解酵素製剤の薬剤学的検討

概要

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Compatibility of 4 lactase preparations (Organase powder, Organase granules Galantase, Lactyme) with 8 drugs was investigated by sensory evaluation method, and residua l activity of each lactase in these mixtures was measured by o-nitrophenyl-β-D-galactopyranoside (ONPG) method to study the relation between compatibility and residual activity, respectively. Residual activity and hydrolysis power of lactase against lactose as substrates were measured in mixtures. Residual activity of each lactase was influenced by aspirin, ascorbic acid, dried aluminum hydroxide gel fine granules. When lactose was used as substrate, Galantase showed lowering of residual activity of lactase by aspirin but great difference was not observed in hydrolysis power of each lactase. It is supposed that the difference of residual activities among lactase preparations correspond to their difference of pH stability. Evident mutual relation was not observed between compatibility and residual activity.
日本医療薬学会の論文
1984-06-20