アムホテリシンB口腔用軟膏の試作と臨床適用

概要

論文の詳細を見る
For the topical application to the treatment of candidiasis in oral cavity, four plastibase oral ointments containing amphotericin B (Fungizone oral suspension) were prepared with adhesive bases; carboxymethyl cellulose sodium salt (CMC-Na), CMC-Na: sodium polyacrylate (PANA) (1:2), CMC-Na: PANA(2:1) and PANA, respectively, Consistencies of four ointments measured with penetrometer, and spreadabilities measured with spreadmeter were not changed when these ointments were incubated at 5℃, 20℃ or 30℃ for 21 days. The amphotericin B content in each ointment measured with HPLC was very stable in each ointment at 5℃, 20℃ and 30℃ for 21 days. Amphotericin B oral ointments were found to be effective for the therapy of patients with candidiasis in oral cavity. Among the four ointments, the ointment containing only CMC-Na used as adhesive base appeared to be the most useful for clinical application, judging from adhesion tests, several sensory tests and therapeutic effect.
日本医療薬学会の論文
1992-08-20