3%ビダラビン軟膏の製剤学的評価

概要

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For the topical application to the treatment of female herpes progenitalis, four different oleaginous ointments containing 3% of vidarabine were prepared with oleaginous bases; plastibase, plastibase with liquid paraffin, plastibase with white petrolatum, and white petrolatum. The amount of vidarabine in each ointment determined by high-performance liquid chromatography with UV detection, was maintained more than 99% of its initial content after 21 days storage at 20℃ or 30 ℃, showing that vidarabine is very stable in each ointment. Consistency of four ointments measured with penetrometer, and spreadability measured with spreadmeter did not change when these ointments were kept at 20℃ or 30℃ for 21 days. Among four oleaginous bases, plastibase was the most useful for clinical application, judging from several sensory tests. We also have obtained preliminary results that vidarabine ointment consisting of plastibase was most effective to the treatment of female herpes progenitalis among four ointments that we prepared.
1988-08-20