The Response of Pseudomonas aeruginosa PAO1 Efflux Pump-Defective Mutants to N-Octanoyl-L-Homoserine Lactone

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概要

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• N-Octanoyl-<sc>L</sc>-homoserine lactone (C8-HSL) is an acyl-homoserine-lactone signal utilized in the quorum-sensing (QS) systems of Burkholderia cenocepacia and other bacterial species. Although also produced by Pseudomonas aeruginosa, its role in this species has not been elucidated. Here, we report that C8-HSL modulated antibiotic resistance and pyocyanin production in a P. aeruginosa efflux pump-deficient mutant. The rhl/las quorum-sensing system and qscR gene were both shown to be nonessential in the C8-HSL-induced changes in ofloxacin resistance, suggesting that P. aeruginosa possesses a distinct pathway to respond to C8-HSL.

• 日本微生物生態学会・日本土壌微生物学会の論文
• 2009-12-01

著者

• YAWATA YUTAKA

  Institute of Life and Environmental Sciences, University of Tsukuba

• UCHIYAMA HIROO

  Institute of Life and Environmental Sciences, University of Tsukuba

• NOMURA NOBUHIKO

  Institute of Life and Environmental Sciences, University of Tsukuba

• MASEDA HIDEAKI

  Institute of Applied Biochemistry, University of Tsukuba

• Uchiyama Hiroo

  Graduate School Of Life And Environmental Sciences Univ. Of Tsukuba

• Uchiyama H

  National Inst. Environmental Studies Ibaraki Jpn

• Uchiyama H

  National Institute For Environmental Studies

• Uchiyama Hiroo

  National Institute Of Environmental Studies

• Uchiyama Hiroo

  Water And Soil Environment Division National Institute For Enviromental Studies

• Nomura Nobuhiko

  Graduate School Of Life And Environmental Sciences Univ. Of Tsukuba

• Nomura Nobuhiko

  Graduate School Of Life And Environmental Sciences University Of Tsukuba

• Nomura Nobuhiko

  Institute Of Applied Biochemistry University Of Tsukuba

• Maseda H

  Institute Of Life And Environmental Sciences University Of Tsukuba

• Maseda Hideaki

  Institute Of Applied Biochemistry University Of Tsukuba

• Yawata Yutaka

  Institute Of Life And Environmental Sciences University Of Tsukuba

• OKABE SATOSHI

  Department of Urban and Environmental Engineering, Graduate School of Engineering, Hokkaido Universi

• ITO AKINOBU

  Department of Urban and Environmental Engineering, Graduate School of Engineering, Hokkaido Universi

• SAWADA ISAO

  Institute of Life and Environmental Sciences, University of Tsukuba

• KURASHIMA HIROAKI

  Institute of Life and Environmental Sciences, University of Tsukuba

• Sawada Isao

  Institute Of Life And Environmental Sciences University Of Tsukuba

• Ito Akinobu

  Department Of Urban And Environmental Engineering Graduate School Of Engineering Hokkaido University

• Nomura Nobuhiko

  Institute Of Life And Environmental Sciences University Of Tsukuba

• Uchiyama Hiroo

  Institute Of Life And Environmental Sciences University Of Tsukuba

• Okabe Satoshi

  Department Of Urban And Environmental Engineering Graduate School Of Engineering Hokkaido University

• Kurashima Hiroaki

  Institute Of Life And Environmental Sciences University Of Tsukuba

• Nomura N

  Institute Of Applied Biochemistry University Of Tsukuba

• Okabe Satoshi

  Faculty Of Engineering Hokkaido University

• Okabe Satoshi

  Department Of Sanitary And Environmental Engineering Faculty Of Engineering Hokkaido University

• UCHIYAMA Hiroo

  Institute of Applied Biochemistry, University of Tsukuba

• UCHIYAMA Hiroo

  Institute of Applied Biochemistry, The University of Tsukuba

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