<Original Article>Investigation into the usefulness and adverse events of CDDP, 5-FU and dl-Leucovorin (PFL-therapy) for advanced colorectal cancer

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概要

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• Biochemical modulation of 5-fluorouracil (5-FU) has been verified the evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. We investigated the therapeutic and adverse drug reaction of intensive chemotherapy using cis-platin (CDDP), 5-FU and dl-leucovorin (LV) (PFL-therapy), which may be producing dual biochemical modulation effect of 5-FU for advanced colorectal carcinoma. Administration schedule was 13 mg/m^2 of CDDP, 300 mg/m^2 of 5-FU, and 30 mg/body of dl-LV for 5 consecutive days. This regimen was repeated at 3-week intervals in hospital. Sixteen patients were enrolled in this study, most of whom had a history of previous chemotherapy as adjuvant treatment, and the response rate was 25%, with four patients having "partial response" and eight "no change". In respect to performance status, 46% of patients who completed the protocol were markedly improved in spite of their poor performance status before treatment. Moreover, when patients were classified into two groups based on changes of the serum level of CEA, "responder in CEA level" showed better prognosis than "non-responder in CEA level". Major toxicifies were nausea, hyperglycemia and neutropenia. Three patients experienced Grade 4 hematological side effect, but these complications resolved quickly in all patients except for one patient. PFL-therapy is effective for advanced colorectal cancer with large tumor burden and showed the same prognostic result as the American and European trials in spite of smaller number of treatment cycles and a history of previous chemotherapy. We will be able to demonstrate the usefulness of this regimen for Japanese patients with advanced colorectal cancers after adding new cases to the present report.

• 東京医科歯科大学の論文

著者

• IWAI Takehisa

  Department of Vascular Surgery, Graduate School, Tokyo Medical and Dental University

• Iwai T

  Tokyo Medical And Dental Univ.

• Iwai Takehisa

  Department Of Surgery And Pediatric Surgery Tokyo Medical & Dental University

• OKABE SATOSHI

  Department of Urban and Environmental Engineering, Graduate School of Engineering, Hokkaido Universi

• ARAI Takehiro

  Department of Surgery, Tokyo Medical and Dental University School of Medicine

• Kuwabara Hiroshi

  Department Of Surgery Tokyo Medical And Dental University

• Okabe Satoshi

  Department Of Urban And Environmental Engineering Graduate School Of Engineering Hokkaido University

• Arai Takehiro

  Department Of Radiological Technology Takase Clinic

• Maruyama Shouji

  Department Of Surgery Faculty Of Medicine Tokyo Medical And Dental University

• UDAGAWA Masaru

  Department of Electronic Engineering, Kogakuin University

• Udagawa Masaru

  Department Of Surgery Tokyo Medical And Dental University

• Udagawa Masaru

  Department Of Electronic Engineering Kogakuin University

• Ishikawa Toshiaki

  Department of Surgery, Tokyo Medical and Dental University

• Tanami Hideaki

  Department of Surgery, Tokyo Medical and Dental University

• Fukahara Toshiaki

  Department of Surgery, Tokyo Medical and Dental University

• Ootsukasa Shunrou

  Department of Surgery, Tokyo Medical and Dental University

• Murase Naoya

  Department of Surgery, Tokyo Medical and Dental University

• Yamashita Hironori

  Department of Surgery, Tokyo Medical and Dental University

• Tanami Hideaki

  Department Of Surgery Tokyo Medical And Dental University

• Murase Naoya

  Department Of Surgery Tokyo Medical And Dental University

• Ishikawa Toshiaki

  Department Of Surgery Tokyo Medical And Dental University

• Fukahara Toshiaki

  Department Of Surgery Tokyo Medical And Dental University

• Yamashita Hironori

  Department Of Surgery Tokyo Medical And Dental University

• Okabe Satoshi

  Department Of Sanitary And Environmental Engineering Faculty Of Engineering Hokkaido University

• Okabe Satoshi/ishikawa

  Department Of Surgery Tokyo Medical And Dental University/department Of Surgery Tokyo Medical And De

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