Enhanced Adhesion of Early Endothelial Progenitor Cells to Radiation-induced Senescence-like Vascular Endothelial Cells in vitro
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概要
- 論文の詳細を見る
The effects of ionizing radiation (IR) on tumor neovascularization are still unclear. We previously reported that vascular endothelial cells (ECs) expressing the IR-induced senescence-like (IRSL) phenotype exhibit a significant decrease in angiogenic activity in vitro. In this study, we examined the effects of the IRSL phenotype on adhesion to early endothelial progenitor cells (early EPCs). Adhesion of human peripheral blood-derived early EPCs to human umbilical vein endothelial cells (HUVECs) expressing the IRSL phenotype was evaluated by an adhesion assay under static conditions. It was revealed that the IRSL HUVECs supported significantly more adhesion of early EPCs than normal HUVECs. Expressions of ICAM-1, VCAM-1 and E-selectin were up-regulated in IRSL HUVECs. Pre-treatment of IRSL HUVECs with adhesion-blocking monoclonal antibodies against E-selectin and VCAM-1 significantly reduced early EPC adhesion to IRSL HUVECs, suggesting a potential role for the E-selectin and VCAM-1 in the adhesion between IRSL ECs and early EPCs. Therefore, the IRSL phenotype expressed in ECs may enhance neovascularization via increased homing of early EPCs. Our findings are first to implicate the complex effects of this phenotype on tumor neovascularization following irradiation.
- Journal of Radiation Research 編集委員会の論文
- 2009-09-16
著者
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Ishii Hideto
Life Science and Bioethics Research Center, Tokyo Medical and Dental University
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Yoshida Masayuki
Life Science and Bioethics Research Center, Tokyo Medical and Dental University
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INOUE Yoshinori
Department of Vascular Surgery, Graduate School, Tokyo Medical and Dental University
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IWAI Takehisa
Department of Vascular Surgery, Graduate School, Tokyo Medical and Dental University
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MIURA Masahiko
Oral Restitut. Grad. Sch. Tokyo Med. Dent. Univ.
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Ishii Hideto
Life Science And Bioethics Research Center Tokyo Medical And Dental Univerity
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Iwai Takehisa
東京医科歯科大学 医歯学総合研究科血管･応用外科学
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Iwai Takehisa
Department Of Surgery And Pediatric Surgery Tokyo Medical & Dental University
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Inoue Yoshinori
東京医科歯科大学 医歯学総合研究科血管･応用外科学
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Yoshida Masayuki
東京医科歯科大学 高齢医療血管医学
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Yoshida Masayuki
Life Science And Bioethics Research Center Tokyo Medical And Dental University
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Igarashi Kaori
Oral Radiation Oncology Department Of Oral Restitution Tokyo Medical And Dental University
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Miura Masahiko
Oral Radiation Oncology Dep. Of Oral Restitution Tokyo Medical And Dental Univ.
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Miura Masahiko
Oral Radiation Oncology Department Of Oral Restitution Tokyo Medical And Dental University
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SERMSATHANASAWADI Nuttawut
Department of Vascular and Applied Surgery, Tokyo Medical and Dental University
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Inoue Yoshinori
Department Of Industrial Medicine Graduate School Of Medicine Osaka City University
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Sermsathanasawadi Nuttawut
Department Of Vascular And Applied Surgery Tokyo Medical And Dental University
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INOUE Yoshinori
Department of Chemistry and Biotechnology, Faculty of Engineering, Yamanashi University
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