<Original Article>Clinicopathological Study of Mucous Pooling Referred to as Mucinous Component (MUC) in Colorectal Submucosal Invasive Carcinomas

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概要

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• We investigated the significance of a pool of mucin, individually termed mucinous component (MUC), at the leading invasion edge of colorectal submucosal invasive carcinoma (SIC). In particular, we studied the correlation between pathological adverse prognostic factors and stainability of the mucosubstances and tumor-associated glycoconjugates in MUC. We demonstrated that MUCs were present in 21% of SICs, and 20% of SICs with MUC were involved in metastasis or recurrence, while only 6% of SICs without MUC were positive for it (p=0.005). SICs with MUC showed strong staining of carcinoembryonic antigen and Ulex europaeus I in the MUCs as well as in the cancer cells with high-grade atypia. Moreover, the mucins in MUCs predominantly stained for sialomucin. This study was the first to investigate the importance of mucous nodules in colorectal SIC. We concluded that MUC in SIC would be an important adverse prognostic factor, and that we should at least consider employing a similar treatment strategy for it to advanced colorectal carcinoma.

• 東京医科歯科大学の論文

著者

• Iwai T

  Tokyo Medical And Dental Univ.

• Iwai Takehisa

  First Department Of Surgery Faculty Of Medicine Tokyo Medical And Dental University

• Kuwabara Hiroshi

  Department Of Surgery Tokyo Medical And Dental University

• Okabe S

  Department Of Surgery Faculty Of Medicine Tokyo Medical And Dental University

• Arai Takehiro

  First Department Of Surgery Tokyo Medical And Dental University School Of Medicine

• Maruyama Shouji

  Department Of Surgery Faculty Of Medicine Tokyo Medical And Dental University

• Udagawa Masaru

  Department Of Surgery Tokyo Medical And Dental University

• Okabe Satoshi

  First Department of Surgery, Tokyo Medical and Dental University

• Ishikawa Toshiaki

  First Department of Surgery, Tokyo Medical and Dental University

• Tanami Shuurou

  First Department of Surgery, Tokyo Medical and Dental University

• Kuwabara Hiroshi

  First Department of Surgery, Tokyo Medical and Dental University

• Fukahara Toshiaki

  First Department of Surgery, Tokyo Medical and Dental University

• Udagawa Masaru

  First Department of Surgery, Tokyo Medical and Dental University

• Ootsukasa Shunrou

  First Department of Surgery, Tokyo Medical and Dental University

• Maruyama Shouji

  First Department of Surgery, Tokyo Medical and Dental University

• Murase Naoya

  First Department of Surgery, Tokyo Medical and Dental University

• Yamashita Hironori

  First Department of Surgery, Tokyo Medical and Dental University

• Tanami Shuurou

  First Department Of Surgery Tokyo Medical And Dental University

• Ishikawa Toshiaki

  Department Of Surgery Tokyo Medical And Dental University

• Fukahara Toshiaki

  Department Of Surgery Tokyo Medical And Dental University

• Yamashita Hironori

  Department Of Surgery Tokyo Medical And Dental University

• Okabe Satoshi/ishikawa

  First Department Of Surgery Tokyo Medical And Dental University/first Department Of Surgery Tokyo Me

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