Pathological study of chronic hepatitis B with interferon treatment with special reference to the histopathological features predicting the efficacy of interferon treatment.

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The histopathological features of chronic hepatitis B were evaluated in 35 biopsy specimens from the 25 patients who had been treated with interferon (IFN). Twenty five biopsies were taken before IFN treatment. These 25 histological diagnoses were chronic active hepatitis (CAH) in 11, CAH with bridging necrosis (BN) in 10, chronic persistent hepatitis in 3 and cirrhosis in 1. In 10 patients, HBeAg was persistently lost after IFN treatment (effective group)and in 15, HBeAg remained positive or transiently lost (ineffective group). The pretreatment biopsies showed a significantly higher incidence of piecemeal necrosis and BN in the effective group than those in the ineffective (p<0.01 and p<0.05, respectively). The cases effective to IFN treatment had two or more histopathological features of PN, BN and/or hepatocellular ballooning in the pretreatment biopsy (p<0.01 or p<0.05). The posttreatment biopsy was done in 8. There was marked histological improvement after treatment.
社団法人日本肝臓学会の論文