Study of receptor binding of human interferon to peripheral mononuclear cells and induction of 2'-5' oligoadenylate synthetase in patients with chronic hepatitis B treated with interferon.

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Ten patients with chronic hepatitis B were treated with interferon (IFN). Changes of the binding of human lymphoblastoid interferon (HLBI) to PBMC and the induction of 2'-5' oligoadenylate synthetase (2-5 AS) in peripheral blood mononuclear cells (PBMC) were determined during IFNtreatment. The mean pretreatment binding of HLBI to PBMC of patients was similar to normal individuals. The binding of HLBI remained unchanged until 10 to 14 days after the first injection of IFN, since then it decreased to 40 to 60 percent of the pretreatment value. 2-5 AS was induced when PBMC was cultured with IFN in vitro before IFN treatment. However, during the treatment, the level of 2-5 AS in PBMC decreased when PBMC was cultured even in the presence of IFN. On the other hand, 2-5 AS remained at a high level during the treatment in vivo. This phenomenon couldn't be accounted for by change in the binding of HLBI to PBMC. IFN administration might induce a new mechanism to maintain high levels of 2-5 AS in vivo.
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