Morphometric quantitation of rat liver sinusoidal endothelial fenestration in various degrees of perfusion pressure.

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Morphometric analysis of sinusoidal endothelial fenestration (SEF) of rat liver was carried out in five degrees of perfusion pressure (5, 10, 20, 30, 50cmH<SUB>2</SUB>O) via the portal vein using scanning electron microscope. In the perfusion pressure at 10cmH<SUB>2</SUB>O, the diameter of SEF in zone 1 was significantly (p<0.001) larger than that in zone 3. The number of SEF in zone 3 was significantly (p<0.001) larger than that in zone 1. The area of SEF per square micron of the endothelial surface in zone 3 was significantly (p<0.05) more than that in zone 1. The SEF having more than 300nm in diameter was noted very infrequently in zone 1 and zone 3, which increased with the rise of perfusion pressure. The size of SEF might be easily changed by the sinusoidal pressure. These results indicate that in the hepatic lobule there is heterogeneity in the number, the diameter and the area of SEF. The present results are important for the investigation of SEF in various kinds of pathological conditions in the liver.
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