ラット肝類洞内皮小孔に及ぼすエタノールの影響

概要

論文の詳細を見る
The alterations of sinusoidal endothelial fenestration (SEF) were elucidated in rats liver acutely or chronically fed ethanol and after withdrawal of ethanol administration using scanning electron microscope. The liver sinusoids were perfused at 10 cmH2O pressure via portal vein and diameter, number and porosity of SEF were analysed morphometrically. There was heterogeneity in size and number of SEF in the hepatic lobule in control rats. In control rats, the diameter of SEF in zone 1 was significantly (p<0.001) larger than that in zone 3 and the number was significantly (p<0.001) more in zone 3 compared with zone 1. The porosity of zone 3 compared with zone 1 was significantly (p<0.05) larger. Chronic ethanol consumption led to significant enlargement (p<0.001) of diameter, decrease (p<0.001) in number and increase (p<0.01) in porosity in zone 3 compared with control. After withdrawal of ethanol administration these changes recovered to the control levels. The present results indicate that the alterations of SEF may play a role in the pathogenesis of alcoholic liver injury.
社団法人日本肝臓学会の論文