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Cell kinetics of hyperplastic lesions, normal liver cells and hepatomas in rats were investigated at different time intervals during carcinogenesis with dietylnitrosamine (DEN) administration by employing 3H-thymidine autoradiography. Furthermore, the reactive proliferative activity of the above menthoned cell populations was examined by 67% hepatectomy during the experimental course. At 12 weeks after DEN administration, hyperplastic lesions had been classified histologically into two types, the one being the nodule of large liver cells, the another the area of large liver cells. Increased labeling indices were observed in both the hyperplastic lesions and normal liver cells during DEN feeding. The labeling indices of the area of large liver cells were from 12% to 16%, and those of nodule of large liver cells and normal liver cells were about 2%. After the partial hepatectomy, both the hyperplastic lesions and normal liver cells showed considerably elevated labeling indices, indicating the reactive proliferative activity.On the other hand, hepatomas showed much higher proliferative activity than the other cell populations, but there was no change observed in the labeling index between before and after the partial hepatectomy. The hyperplastic lesions and normal liver cells were apparently reactive to partial hepatectomy, whereas the hepatomas showed almost no such response.From these results, it is concluded that the hyperplastic lesions maintained the control of cell proliferation, so that those lesions were distinct from hepatomas in the kinetics of the cell proliferation.

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