Cell kinetic analysis of hyperplastic lesions appearing in early phase of hepatocarcinogenesis.

概要

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Hyperplastic lesions such as foci and nodules (HNs) appearing in early phase of rat hepatocarcinogenesis according to Solt and Farber were analyzed by bromodeoxyuridine labeling methods and cytofluoromerty. In this cytofluorometry, placental form of glutathione s-transferase was used as a marker for extreme microlesions such as cell foci.<BR>Cell foci were the proliferative cell population of mononuclear diploid cells and their labeling indices (LI) were about 30%. In the developing process from cell foci to HNs, LI decreased gradually. Consequently, the LI of early HNs were only 2%. The ploidy patterns of HNs showed the various proportion of diploid and tetraploid cells. Especially, the HNs composed mainly of tetraploid cells seem to be remodeling because of the similarity in the ploidy pattern to normal liver tissue.
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