肝細胞癌における変異型p53遺伝子発現の免疫染色化学的検討

概要

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Mutations of p53 gene which controls normal cell growth have been reported in many malignancies. By standard immunohistochemical techniques, these altered gene products are detected in the nuclei of the tumor cells. In this study, we made an immunohistochemical analysis for the expression of p53 protein in 30 cases of hepatocellular carcinomas (HCCs). p53 protein was absent in all four well-differentiated HCCs and detected in two out of 16 (12.5%) moderately, five out of 10 (50.0%) poorly differentiated HCCs. Furthermore, the expression of p53 protein was significantly correlated with the increased cell proliferative activity as detected by the Ki-67 staining. Thus, our data suggest that the p53 gene mutation in hepatocellular carcinoma occurs in the tumor with low cellular differentiation and high proliferative activity.
社団法人日本肝臓学会の論文