急性アルコール投与時の肝血行動態 : Radioactive Microsphere method を用いた検討

概要

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The effect of ethanol on hepatic blood flow was elucidated in rats acutely fed ethanol using radioactive microsphere method. Acute administration of ethanol increased hepatic blood flow, induced by the increase in portal blood flow from the stomach and the small intestine. In the rats administered ethanol per os, portal blood flow significantly increased at low blood ethanol level (BEL) and had no significant correlation with BEL. In the rats intravascularly administered ethanol, portal blood flow showed no increase at low BEL but significantly increased at high BEL. In the both of the rats orally and intravascularly administered ethanol, hepatic arterial blood flow had a tendency to decrease at low BEL but significantly increased at high BEL.<BR>The present results indicate that the increase in hepatic blood flow may compensate the hepatocellular hypoxia which is induced by the direct effect of ethanol on the local mucosal blood flow in gastrointestinal tracts.
社団法人日本肝臓学会の論文