総胆管結紮ラット肝における増殖肝内胆管系上皮細胞の超微形態--3H-thymidineによる光顕ならびに電顕オ-トラジオグラフィ-による観察を含めて

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The common bile ducts of three rats were ligated, and the ultrastructures of proliferating biliary epithelial cells were studied at 9 days after the ligation. At that time the proliferative cells indicated by 3H-thymidine autoradiography (flash labelling autoradiography) were recognized. <BR>On the nineth day after the ligation, we found marked proliferation of the small interlobular bile ducts as well as ductules in the portal area. About 9.8% of the biliary epithelial cells were found to be labelled. The labelled cells were not confined in any particular area or zone, but scattered at random. In electron microscopic study, we distinguished two types of cell in the proliferated biliary ducts and ductules on the basis of develpment of r-ER and the number of mitochondria. One cell type has well-developed membrane system of r-ER and an increased number of mitochondria. Another has a poorly-developed r-ER and a few mitochondria. The former cell type was predominant in the proliferated bile ducts and ductules. On the other hand, the development of Golgi apparatus varied from cell to cell, and no relationship was noted between the development of Golgi and the development of r-ER. The label with 3H-thymidine was found over nuclei of both ER-rich cells and ER-poor cells. This indicates that each variant of the biliary epithelial cells has a proliferative activity, and there exist no specific type of cell which feed the population of the biliary epithelial cells after common bile duct ligation.

総胆管結紮ラット肝における増殖肝内胆管系上皮細胞の超微形態--3H-thymidineによる光顕ならびに電顕オ-トラジオグラフィ-による観察を含めて

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