肝疾患におけるガラクト-ス静脈負荷試験の臨床的検討

概要

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This study investigates the significances of intravenous galactose tolerance test in the patients with various liver diseases. Galactose was given by rapid intravenous injection (350mg/kg. standard body weight) to 139 subjects, and blood galactose was determined by a specific galactose oxidase method.<BR>The mean values of T1/2 (the half life of injected galactose) were 11.5±1.5minutes (SD) in normal adults, 43.1 minutes in subacute hepatitis, 21.9 minutes in acute stage of acute hepatitis, 16.3 minutes in recovery stage of acute hepatitis, 16.5 minutes in inactive type of chronic hepatitis, 18.7 minutes in active type of chronic hepatitis, 24.9 minutes in liver cirrhosis, 16.4 minutes in gallstone (obstructive jaundice), 13.9 minutes in diabetes mellitus (without liver damage), and 10 minutes in Dubin-Johnson Syndrome. Statistically significant correlations were found between T 1/2 values and histological findings of liver specimens such as liver cell necrosis, liver cell degeneration and liver fibrosis. And also the significant correlations were noted between T 1/2 values and standard liver function tests such as BSP test, ICG test, γ-globulin, total protein, ZTT, GOT, GPT and choline esterase levels. It was suggested that the prolongation of T 1/2 values was as clinically significant as retardation of ICG test, in diagnosing the patients with liver cirrhosis.
社団法人日本肝臓学会の論文