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The effect of taurocholate on uptake and excretion of ICG was investigated in male Wistar rats using hemoglobin-free non-recirculating liver perfusion. The area where ICG was taken up by the hepatocytes could be observed from the surface of the liver with stereomicroscope.<BR>The hepatic uptake and excretion of ICG obeyed Michaelis-Menten kinetics and were thought to be compatib1e with carrier mediated transport. ICG uptake was not affected with taurocholate, while excretion was increased following taurocholate infusion. When the low concentration of ICG was infused, Vmax and Km of ICG excretion were changed according to the concentration of taurocholate infused. ICG was taken up in hepatocytes in decreasing concentration gradient from the periportal to the pericentral zone of the hepatic lobule. However, the higher concentration of ICG abolished the gradient.<BR>These results suggest that heterogeneity within the hepatic lobule exists for uptake and excretion of taurocholate and affects ICG excretion.
社団法人日本肝臓学会の論文