Systemic and hepatic hemodynamics in the experimental liver cirrhosis induced by thioacetamide administration.

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Systemic and hepatic hemodynamics in the experimental liver cirrhosis induced by thioacetamide treatment were evaluated using radioactive microsphere method. The histology of the rats was compatible with liver cirrhosis in human. In the cirrhotic rats, portal pressure and portal systemic shunting significantly increased compared with the controls. The increase of the portal venous inflow resulted from the systemic and splanchnic hyperdynamic circulation and the elevation of the portal venous resistance was observed in cirrhotic rats. These phenomena result in portal hypertension in the cirrhotic rats. Effective hepatic blood flow was decreased in the cirrhotic rats in spite of the increase of the portal venous inflow.<BR>The thiocetamide induced cirrhotic rats showed a similar pathogenesis in the portal hypertension in the cirrhosis in human. Therefore, this model might be suitable for the study of the hemodynamics in the portal hypertension in cirrhosis.
社団法人日本肝臓学会の論文