B型慢性肝炎に対するインターフェロン単独療法後の長期経過観察例の検討

概要

論文の詳細を見る
Fifteen patients with HBeAg positive chronic type B hepatitis were treated with interferon (IFN) and followed up for 18 to 39 months after end of IFN treatment. Thirteen patients received a single course of IFN-αor IFN-βtreatment and two received two courses of IFN-βand IFN-α, and IFN-βand recombinant IFN-αA treatment, respectively. IFN was given daily for 4 weeks. Total dose of IFN administered was 1×10<SUP>8</SUP>IU to 4.77×10<SUP>8</SUP>IU. Five (33.3%) of 15 patients become seronegative for HBeAg just after treatment and 2 patients (13.3%) seroconverted to anti-HBe. Six patients (40%) lost HBeAg 18 months after treatment and no more patients lost HBeAg after that period. Three (20%) seroconverted to anti-HBe 12 months after treatment and this figure remained unchanged even after 12 months. Six (42.8%) of 14 patients lost DNA polymerase (DNAP) from serum and about 40% of the patients were DNAP negative after 12 months. Two (13.3%) of 15 patients lost HBV DNA from serum just after treatment, but all patients become HBV DNA positive in serum after 18 months. Two patients with persistently high level of anti-HBe showed sustained elevation or fluctuation of SGPT in whom both DNAP and HBV DNA were positive in serum.
社団法人日本肝臓学会の論文