:The Effect of Cysteamine on the Duodenal Mucus

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We studied the mechanisms of cysteamine-induced duodenal ulcer, investigating the effect of cysteamine on the duodenal mucus.Forty adult, male Wistar rats received subcutaneous injection of cysteamine (30mg/100g body weight) and were sacrificed at various intervals. Seven rats were prepared for the control study. Morphological changes of the duodenal mucosa were observed by stereomicroscopy followed by hiatoligical investigations of the Brunner's glands and crypts of Lieberkuhn on the semi-thin H-E and PAS stained sections. For the quantitative analysis of PAS-positive mucin, a newly developed computerized color image analyzer was used. Eighteen rats with truncal vagotomy were also examined by the same method.Erosion developed at 6h. and ulcer at 12h. after cysteamine administration. On the other hand, the PAS-positive mucin of the Brunner's glands was moderately reduced at 3h., then markedly at 6 and 12h.. At these periods, the lumina of the glands were found to be dilated, which suggested serous hypersecretion. Goblet cells and brush borders of crypts of Lieberkuhn also showed marked reduction in PAS-positivity at 6 and 12h., when dilatation of some crypts were observed. The changes of these glands were recovered at 24 and 48h.In the vagotomized rats, no ulcerative lesions developed by the cysteamine administration. However, PAS-positive mucin of the Brunner's glands was also markedly reduced at 6 and 12h., whereas neither dilatation of the glands nor remarkable changes of crypts were observed.It was demonstrated that reduction of PAS-positive mucin of the Brunner's glands and crypts of Lieberkuhn occurred before the ulcerative lesions developed and that the mucus-reducing effects of cysteamine on the Brunner's glands was not inhibited by vagotomy.
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:The Effect of Cysteamine on the Duodenal Mucus

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