Changes in hexosamine metabolism in rat gastric mucosa following oral administration of acetic acid-glycerin mixture. Histochemical and biochemical analyses.:Histochemical and biochemical analyses

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Changes in metabolism of mucus in rat gastric mucosa following oral administration of acetic acid-glycerin solution were investigated. Hexosamine content reduced remarkablly 3hrs after administration and showed a recovery to normal level on 2nd day of administration. Both glucosamine synthetase and glucosaminidase activities also showed significant decreases 3hrs after administration. Glucosamine synthetase activity then showed a gradual increase and reached a plateau after 12hrs of administration. Thereafter, a gradual decrease in glucosamine synthetase activity was observed. On the other hand, the activity of glucosaminidase progressively elevated until 7th day of administration. These results indicate that the recovery of glucosamine synthesizing system precedes the accumulation of hexosamine and suggest that the content of hexosamine in gastric mucosal lesions following administration of acetic acid-glycerin mixture may be regulated by both glucosamine synthetase and glucosaminidase. The results presented in this study also indicate that the model for gastric mucosal lesions used in the present study is a useful experimental tool to investigate the regulatory mechanism for gastric glycoprotein metabolism during formation and recovery of gastric mucosal lesions.
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