Isolation and Identification of Hypotensive Substances in Chlorella Extract
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概要
- 論文の詳細を見る
We attempted isolation of the hypotensive substance contained in hot water extracts of chlorella raw cells. When chlorella extracts were fractionated by gel filtration, fraction E showed a depressive effect. Blood pressure of SHR and SHRSP showed falls of about 60mmHg at 1 hour after intravenous administration and of 30 to 40mmHg at 2 hours after intragastric administration. Fraction E was subsequently purified by passage through a column of Sephadex G-10, and then crystallized from ethanol. Both the crystalline compound and the mother liquor showed hypotensive effects, but the effect of the latter was more potent. The crystalline compound was identified as adenosine by means of chemical and physical methods, and the mother liquor was considered to be a mixture of adenosine and an unknown compound containing glycine. As a result, the hypotensive effect of fraction E on SHR and SHRSP may be ascribable to adenosine or to an oligopeptide with a molecular weight of approximately 200.
- International Heart Journal刊行会の論文
著者
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Kakehi Kazuaki
Department Of Biopharmaco Informatics School Of Pharmacy Kinki University
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Murakami Tetsuo
Research Institute Of Food Science Kinki University
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Okamoto Kozo
Department Of Palhology Faculty Of Medicine Kyoto University
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Honda Susumu
Department Of Pharmacy School Of Pharmacy Kinki University
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Miyake Hideo
Department Of Electrical And Electronic Engineering Mie University
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Iizuka Yoshitomi
Research Institute Of Food Science Kinki University
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MATSUBARA Yoshiharu
Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University
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YOKOI Katsumi
Department of Applied Chemistry, Faculty of Science and Technology, Kinki University
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Okamoto Kozo
Department of Clinical Functional Physiology, Toho University
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Kakehi Kazuaki
Department of Analytical Chemistry, Kinki University School of Pharmacy
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Honda Susumu
Department of Pharmaceutical Analysis, Kinki University
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Matsubara Yoshiharu
Department of Applied Chemistry, Kinki University School of Science and Technology
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