Isolation and Identification of Hypotensive Substances in Chlorella Extract
スポンサーリンク
概要
- 論文の詳細を見る
We attempted isolation of the hypotensive substance contained in hot water extracts of chlorella raw cells. When chlorella extracts were fractionated by gel filtration, fraction E showed a depressive effect. Blood pressure of SHR and SHRSP showed falls of about 60mmHg at 1 hour after intravenous administration and of 30 to 40mmHg at 2 hours after intragastric administration. Fraction E was subsequently purified by passage through a column of Sephadex G-10, and then crystallized from ethanol. Both the crystalline compound and the mother liquor showed hypotensive effects, but the effect of the latter was more potent. The crystalline compound was identified as adenosine by means of chemical and physical methods, and the mother liquor was considered to be a mixture of adenosine and an unknown compound containing glycine. As a result, the hypotensive effect of fraction E on SHR and SHRSP may be ascribable to adenosine or to an oligopeptide with a molecular weight of approximately 200.
- International Heart Journal刊行会の論文
著者
-
Kakehi Kazuaki
Department Of Biopharmaco Informatics School Of Pharmacy Kinki University
-
Murakami Tetsuo
Research Institute Of Food Science Kinki University
-
Okamoto Kozo
Department Of Palhology Faculty Of Medicine Kyoto University
-
Honda Susumu
Department Of Pharmacy School Of Pharmacy Kinki University
-
Miyake Hideo
Department Of Electrical And Electronic Engineering Mie University
-
Iizuka Yoshitomi
Research Institute Of Food Science Kinki University
-
MATSUBARA Yoshiharu
Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University
-
YOKOI Katsumi
Department of Applied Chemistry, Faculty of Science and Technology, Kinki University
-
Okamoto Kozo
Department of Clinical Functional Physiology, Toho University
-
Kakehi Kazuaki
Department of Analytical Chemistry, Kinki University School of Pharmacy
-
Honda Susumu
Department of Pharmaceutical Analysis, Kinki University
-
Matsubara Yoshiharu
Department of Applied Chemistry, Kinki University School of Science and Technology
関連論文
- Augmentation of Spontaneous Hypertension by Chronic Stress in Rats
- Adrenal Catecholamine Content in the Spontaneously Hypertensive Rats
- Enzyme-histochemical Studies on the Brain Stem of Spontaneously Hypertensive Rats
- Studies on the Autonomic Nervous System of Spontaneously Hypertensive Rats
- Enzyme Histochemical Studies on the Hypothalamus of Spontaneously Hypertensive Rates : With Special Reference to That of Rats Subjected to Various Endocrinc Interferences
- Pharmacodynamic Studies on the Cardiovascular System of Spontaneously Hypertensive Rats
- Further Observations of the Development of a Strain of Spontaneously Hypertensive Rats
- Experimental Hypertension and Hypotension Induced by Hypothalamic Destruction in the Rat
- Adsorption Properties of As(III) and Cr(VI) in Water Environment by Calcined Gibbsite
- Relationship between Anion Adsorption and Physicochemical Properties of Aluminum Oxide
- PLASMA RENIN AND HYPERTENSIVE VASCULAR COMPLICATIONS : AN OBSERVATION IN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT
- Microstructure of Cu(In,Ga)Se_2 Films Deposited in Low Se Vapor Pressure
- Dermatomyositis Accompanied by Rectal Cancer : Report of a Case
- Hypotensive Effects of Peptide Substances Separated from Different Protein Sources in Foods Given SHRSP and SHR
- Cardiovascular Diseases in the Spontaneously Hypertensive Rat
- The Depressor Principle in the Kidney of the New-born Rat : I. SOME BIOLOGICAL AND PHYSICOCHEMICAL PROPERTIES OF THE KIDNEY EXTRACT OF THE NEW-BORN RAT
- Primary Choriocarcinoma of the Jejunum : Report of a Case
- EARLY CARCINOMA OF THE APPENDIX VERMIFORMIS
- Importance of Genetic Factors in Stroke--An Evidence Obtained by Selective Breeding of Stroke-prone and -resistant SHR (3 Conference of Pathogenesis of Hypertension)
- Baroreceptor Function Revealed by Acute Sinoaortic Denervation in Spontaneously Hypertensive Rats
- Hypothalamic Tonic Regulation of Blood Pressure in Spontaneously Hypertensive Rats
- Experimental Studies on the Pathogenesis and Prophylaxis of Stroke in Stroke-prone Spontaneously Hypertensive Rats(SHR) : (1) Quantitative Estimation of Cerebrovascular Permeability
- VASCULAR LESIONS IN THE VARIOUS SUBSTRAINS OF SPONTANEOUSLY HYPERTENSIVE RATS AND THE EFFECTS OF CHRONIC SALT INGESTION
- DEVELOPMENT OF SUBSTRAINS IN SPONTANEOUSLY HYPERTENSIVE RATS: GENEALOGY, ISOZYMES AND EFFECT OF HYPERCHOLESTEROLEMIC DIET
- Distribution Profiles and Annealing Characteristics of Defects in GaAs Induced by Low-Energy FIB Irradiation : Electrical Properties of Condensed Matter
- Fluorescence Microscopical Studies on Noradrenaline in the Peripheral Blood Vessels of Spontaneously Hypertensive Rats
- EFFECTS OF HIGH OR LOW SODIUM INTAKE IN SPONTANEOUSLY HYPERTENSIVE RATS
- Structures of New Cyclic Peptides in Young Unshui (Citrus unshiu MARCOV.), Orange (Citrus sinensis OSBECK.) and Amanatsu (Citrus natsudaidai) Peelings(Organic Chemistry)
- En Bloc Surgery for Colon Cancer : Report of a Case
- Genetic Analysis of Blood Pressure in Spontaneously Hypertensive Rats
- Deviation of Central Norepinephrine Metabolism in Hypertensive Rats
- CARDIOVASCULAR LESIONS IN THE SELECTIVELY-BRED GROUP OF SPONTANEOUSLY HYPERTENSIVE RATS WITH SEVERE HYPERTENSION
- Genetic Factors Involved in Spontaneous Hypertension in Rats An Analysis of F_2 Segregate Generation
- Participation of Neural Factor in the Pathogenesis of Hypertension in the Spontaneously Hypertensive Rat
- Chromaticity Coordinate Analysis on the Translucent Preparations Stained with Weigert's Method
- The Spontaneously Hypertensive Rat (SHR) : An Animal Model for Hypertension Research
- Effects of Low or High Sodium Diet in Stroke-prone Spontaneously Hypertensive Rats
- Structure and Physiological Activity of Phenyl Propanoid Glycosides in the Leaf of Hinoki(Chamaecyparies obtusa SIEB. et ZUCC.)(Organic Chemistry)
- Ultra Microanalysis of Ferric Ion Using Triazene and Capillary Electrophoresis
- Effects of three kinds of single cell proteins on blood pressure, cerebral stroke lesions and hypertensive vascular changes in SHRSP
- Color Specification of the Weigert-Stained Elastic Fibers of the Nuchal Ligament
- Vascular Changes in the Various Substrains of Spontaneously Hypertensive Rats, Untreated and Treated with Sodium Chloride in Diet
- Metabolism of Adrenal Corticosteroids in Spontaneously Hypertensive Rats
- The Spontaneously Hypertensive Rat (8) : Proceedings of VIII Annual Scientific Meeting of the Council for the Spontaneously Hypertensive Rat October 8, 1972, Nagasaki
- True left-sided gallbladder with a portal anomaly : report of a case
- Effects of Diets Initiated at the Hypertensive Stage on SHRSP Blood Pressures, Life-spans and Incidences of Stroke Lesions
- On the Hypotensive Flavonoids in Young Barley Leaves (Part 2). Di-C-gluco-sylflavone
- Hypotensive Substances in Citrus Fruit Peels
- On the Hypotensive Substances in Chlorella Extract
- Effects of Chlorella Alkali Extract on Blood Pressure in SHR
- Further Purification of a Macromolecular Hypotensive Substnace in Fomes pinicola
- On the Separation, Purification and Structural Determination of Hypotensive Substance in Lemmon Peels (2)
- On the Hypotensive Substances in Basidiomycetes Drugs
- Effect of Nutritional Improvement and Antihypertensive Treatment on blood Pressure, Cerebral Stroke Lesions and Life-span in SHRSP
- On the Hypotensive Substances of Bamboo Leaves
- Isolation and Identification of Hypotensive Substances in Chlorella Extract
- Structure and Hypotensive Effect of Flavonoid Glycosides in Citrus unshiu Peelings
- Studies on Stroke in Stroke-Prone Spontaneously Hypertensive Rat (SHRSP):(II) Cerebrovascular Fat Deposition and Cerebrovascular Permeability
- Studies on Stroke in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP):(I) Local Factor Analysis on Stroke
- Dietary Effects on Blood Pressure and Incidence of Stroke in SHRSP:(2) Effects of Protein Sources Received Some Treatment
- The Therapeutic Effect of Several Anti-hypertensive Drugs and Diet on M-SHRSP:Changes in Life Spans, Blood Pressures, Plasma Hormones, Fundus Oculi and Internal Organs. (Second report)
- Basement membrane protein in microvessels of the optic nerve of SHRSP
- Hypertensive Papilledema in M-Strain Stroke-Prone Spontaneously Hypertensive Rats
- Ophthalmological Studies on the M-Strains of Stroke-Prone Spontaneously Hypertensive Rat
- Findings in the blood vessels of the eyes, brains, kidneys, and other organs of M-SHRSP
- The Therapeutic Effects of Several Anti-hypertensive Drugs and Diet on M-SHRSP:Changes in Life Spans, Blood Pressures, Plasma Hormones, Fundus Oculi and Internal Organs
- Fluorescein angiographic changes in generalized narrowing or caliber irregularity of retinal arteriole in M-SHRSP
- The effects of certain antihypertensive drugs and diet on M-SHRSP:Prevention and therapeutic effects when administered at different stages of life
- The Effects of Several Anti-hypertensive Drugs on Vascular Changes to Organs on M-SHRSP and SHRSP
- Changes in plasma aldosterone and other phenomena in M-SHRSP, SHRSP and SHR
- The therapeutic effects of SQ 29, 852 and manidipine on M-SHRSP with cerebrovascular lesions:General progress following treatment. (First report)
- The relation between long-term administration of SQ 29, 852 and manidipine and healing angionecrosis in M-SHRSP and SHRSP
- The therapeutic effects of SQ 29, 852 and manidipine on M-SHRSP with cerebrovascular lesions:Brain and organ vascular changes (Second report)
- Arterial. Disturbance in SHRSP as Observed by Comparison among Aorta, Coronary Artery and Cerebral Artery
- A Study on Coronary Damage in SHRSP:The Determination of Medial Tissue Collagen
- The damages of aorta and coronary artery in SHRSP:synthetic estimation of smooth muscle cell and connective tissues contents by principal component analysis
- The damage of aorta in SHRSP:the estimation of smooth muscle cell and connective tissues contents
- A Study on Coronary Disorders in SHRSP:The Determination of Medial Tissue Elastin
- The transition of the medial acid mucopolysaccharides value in the thoracic aorta of SHRSP with aging
- Day-Old Characteristics of Cerebroarterial Disturbance in SHRSP Determination of cell and intercellular matrix
- Studies on the Monoamine Oxidase in Spontaneously Hypertensive Rats
- Prophylactic Effect of Diet Fed from the Hypertensive Stage on the Development of Cerebral Stroke Lesions in SHRSP
- Increased Vascular Permeability as a Causative Factors in the Development of Cerebrovascular Lesions in SHR
- Investigation of Water and Electrolyte Balance in Stroke-Prone SHR
- Orientation of "Unit" Elastic Lamellae within the Media of the Rat Aorta
- Effects of Bilateral Carotid Artery Ligation with SHR on Plasma Lipoperoxide and High Density Lipoprotein (HDL)-Cholesterol Level
- The transition of the medial smooth muscle cell fiber in the thoracic aorta of SHRSP with aging
- The damage of coronary artery in SHRSP:the estimation of smooth muscle cell and connective tissues contents
- Determination of Aortic Medial Tissue Glycoprotein (GP) in Stroke-Prone Hypertensive Rats
- High molecular weight renin in the plasma and kidney of SHRSP
- Changes in platelet function due to hypertension. Appearance of "exhausted" platelets due to long duration of hypertension and stroke
- Prophylactic Effects of Diets Composed of Various Proteins on the Development of Cerebrovascular Lesions in SHRSP:Changes in Lipoprotein Metabolism
- On Hypotensive Substances in Plants (II)
- Effects of Peptide Substances Separated from Several Protein Sources (White Fish Meal, Euphausia etc) on Blood Pressure in SHRSP
- Dietary Protein Utilization and Intestinal Amino Acid Absorption in SHRSP and WKY
- On the Hypotensive Substances in Plants:(2) Fractionation of Plant Extracts and Mechanism of Their Action
- Dietary Effects on Blood Pressure and Incidence of Stroke in SHRSP:(1) Effects of Various Protein Sources
- Prophylactic Effect of Diets Fed from the Hypertensive Stage on the Development of Cerebral Stroke Lesions in SHRSP:Comparison of Protein Diets of Animal and Plant Origins
- Prophylactic Effects of Beef-Meat Diet on the Development of Cerebrovascular Lesions in SHRSP-Changes in Lipoprotein Metabolism
- On the Hypotensive Substances in Plants:(1) Method for Extraction and Effects on Blood Pressure in Rats