Vascular Changes in the Various Substrains of Spontaneously Hypertensive Rats, Untreated and Treated with Sodium Chloride in Diet

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概要

• 論文の詳細を見る

• (1) There were definite differences in incidence of the hypertensive vascular changes in the brain and kidneys among the substrains of SHR.(2) The loading of sodium chloride in drinking water accelerates the development of hypertensive vascular changes and sequential pathological changes in the brain and kidneys of SHR.(3) The substrains A3 and C of SHR have a peculiar nature with regard to cerebrovascular diseases. A3 develops spontaneously cerebrovascular diseases with a high incidence, and shows the highest incidence of the changes among various substrains by salt loading. The substrain C shows the lowest incidence of cerebrovascular diseases in the nontreated animals as well as in the NaCl group. This substrain does not appear to be salt-sensitive.(4) These facts suggest that inherited factors play an important role in developing hypertensive vascular diseases.

• International Heart Journal刊行会の論文

著者

• Tomimoto Kazuhiko

  Department Of Cardiology Shizuoka Central Prefectural Hospital Shizuoka

• Okamoto Kozo

  Department Of Palhology Faculty Of Medicine Kyoto University

• Ooshima Akira

  Department Of Pathology Faculty Of Medicine Kyoto University

• Hazama Fumitada

  Department Of Pathology Kyoto University Faculty Of Medicine:max-planck Institut Fur Psychiatrie:(pr

• Hazama Fumitada

  Department Of Pathology Kyoto University School Of Medicine

• TOMIMOTO Kazuhiko

  Department of Pathology, Faculty of Medicine, Kyoto University

• Hazama Fumitada

  Deparment of Pathology, Shiga University of Medical Science, School of Medicine

• Okamoto Kozo

  Department of Clinical Functional Physiology, Toho University

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