The Effects of Several Anti-hypertensive Drugs on Vascular Changes to Organs on M-SHRSP and SHRSP
スポンサーリンク
概要
- 論文の詳細を見る
Captopril, SQ 29852, hydralazine or a combination therapy was administered to 11-week-old male M-SHRSP and 20- to 25-week-old male SHRSP all of which evidenced angionecrosis in verious organs. Blood pressures for captopril or SQ 29852 or hydralazine groups slightly lowered to about 220mmHg, and those of combination therapy groups decreased within normal range. In captopril, SQ 29852 and combination group, fibrinoid substances of blood vessels were absorbed and disappeared, and vacuoles were found in vessel wall, and smooth muscle cells proliferated and, then, blood vessels repaired. These latter effects were not seen in the rats given hydralazine.
- International Heart Journal刊行会の論文
著者
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Okamoto Kozo
Department Of Palhology Faculty Of Medicine Kyoto University
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Ohta Yoshio
Department Of Anesthesia Faculty Of Medicine University Of Tokyo
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Shiokawa Hiroki
Department of Pathology, Kinki University School of Medicine
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Chikugo Taka-aki
Department of Pathology, Kinki University School of Medicine
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Shiokawa Hiroki
Department of Pathology,Kinki University School of Medicine
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