12 罹病ジャガイモ塊茎に見出される新抗菌性物貭Rishitinの構造

概要

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A new antifungal compound, designated as rishitin, has been isolated from tuber tissues of white potatoes (Solanum tuberlosum and S. demissum) infected by an incompatible race of Phytophthora infestans. Rishitin (I) has biological properties qualified as "phytoalexin," and its (planar) structure and the absolute configuration of C-7 have been established as represented by formula I on the basis of chemical and spectral data. The configurations of the remaining three asymmetric centers, C-2, C-3 and C-4, are also discussed from the NMR spectra of I and its dihydrodibromo derivative (V), and formula IA or IB is tentatively proposed. The partial synthesis of I from santonin (VII) has been attempted (Chart I and II) and a compound having the shale R_f value and IR spectrum as I has been obtained.
天然有機化合物討論会の論文
1967-09-25