89(P81) 薬用植物のストレス化合物と生薬成分(ポスター発表の部)

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Phytoalexins are antimicrobial stress compounds synthesized by plants after their exposure to microorganisms. During the course of our studies on stress metabolites from vegetables, we have found several new types of compounds. As an extension of the studies, medicinal plants were screened for the production of stress compounds. In the course of the study, we found that the root tissues of Glehnia littoralis (Umbelliferae) produced antifungal furanocoumarins psoralen (1), xanthotoxin (2), and bergapten (3) after stress treatment (slicing, UV-irradiation, or bacterial inoculation) followed by incubation. Although the compounds 1-3 have been reported as constituents of a crude drug Glehnia root, they were barely detectable in the fresh roots. A time-course study on the treated tissues showed greatly increasing concentrations of 1-3 after stress treatment. Next, the crude drug was prepared under several different conditions. The contents of 1-3 in the crude drug showed considerable variation depending on the method of storage and/or processing of raw material. Slow drying seemed to increase the amounts of 1-3. Similar results were obtained in other umbelliferous medicinal plants: Angelica acutiloba and A. acutiloba var. sugiyamae. Ledebouriella seseloides also gave 1-3 as stress compounds. Inoculation with Pseudomonas cichorii of root slices of Paeonia lactiflora (Paeoniaceae) resulted in the formation of hederagenin (9) as a stress compound. Hederagenin has been reported as a major constituent of callus tissue of P. lactiflora and isolated as a minor constituent of Paeoniae Radix, which is one of the most important crude drugs in traditional medicine. The present findings suggest that some reported constituents of other crude drugs could be also stress metabolites produced during processing. Furthermore, stress compounds could be used as markers to evaluate processing procedure of crude drugs.
1998-08-31

89(P81) 薬用植物のストレス化合物と生薬成分(ポスター発表の部)

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