黄耆の化学的品質評価

概要

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The amounts of five isoflavonoids (I-V) and astragalosides I-IV contained in Astragali Radix were assayed by HPLC. The quality of Astragali Radix was chemically evaluated by the amounts of five isoflavonoids, four astragalosides and y-aminobutyric acid (GABA) contained, the molar ratio of L-canavanine to L-arginine (CANA/Arg), and by the microscopic detection of calcium oxalate crystals. Isoflavonoids I-V, astragalosides I-IV and GABA were detected in Astragali Radixes prepared from Astragalus membranaceus, cultivated in Japan, and in most of the imported Astragali Radixes samples (huanggi in Chinese, 黄耆 or 黄〓). The values of CANA/Arg of these samples were above 1.5. In imported Hedysari Radixes (honggi, 紅耆 or 紅〓) samples prepared from Hedysarum polybotrys, isoflavonoids II, V, GABA and calcium oxalate crystals were detected and their CANA/Arg values were less than 0.1. However, some imported Astragali Radixes (honggi) samples contained only astragalosides I-IV, and no detectable amount of isoflavonoids I-V or of calcium oxalate crystals. The amounts of isoflavonoids I-IV and astragalosides I-IV in Astragali Radixes, prepared from A. membranaceus cultivated in Hokkaido, concomitantly decreased as the diameter of the samples increased.
日本生薬学会の論文
1994-12-20